Skin rash in leukemia
Typically, cutaneous manifestations in leukemia does not necessarily appear before already have other clinical signs, for example, changes in the blood, swollen lymph nodes, and bone marrow. Most often skin rash in leukemia occurs when the patient has already seen the full and expanded clinical symptomatology of leukemia
Still in the medical community and has not been clinically proven the nature of occurrence of leukemia.
We can say that the origin of this disease is still unknown, some doctors believe that leukemia is the result of genetic factors that may lead the patient to a predisposition to the development of leukemia.
Genetic factors may be activated under certain external influences, for example, it can be:
- Exposure to chemicals,
- The impact on the patient viruses.
- Also often genetic factors come into active phase in the use of vaccination.
Most modern domestic and foreign researchers suggest that the basis of leukemia lies hyperplastic tumor process in hematopoietic tissue.
While cutaneous manifestations in leukemia can be divided into two parts:
- specific lakeside,
- nespetsificheskie leukemia
The clinical picture
Note that in leukemia skin lesions are necessarily manifestations of acute leukemia. For this type of diseases are myeloid leukemia, lymphoblastic leukemia, and not differentiated monoblastic leukemia. But in the General clinical picture of these cutaneous manifestations occur in half of all patients.
If we are talking about non-specific leukemia, the characters hemorrhages, prigovorennye rashes, urticaria.
While the largest group of patients with skin lesions in leukemia refers to hemorrhagic syndrome.
This syndrome is found in about 80 percent of all patients diagnosed with acute leukemia. Hemorrhagic syndrome develops acutely, the skin is quickly covered with crimson and bluish spots of rash.
Appears bleeding gums, much less the bleeding can be from the genitals, and nose. Note that the skin rash does not disappear and does not change when strong pressure is applied, and such eruptions are common. Often located on the skin of the trunk and practically does not affect the limbs and face.
Specific leukemia in acute leukemia is usually distributed around the skin in the form of well-defined and tight knots. When pressed you can feel the light pain, and so the value of the node ranges from a small pea to the size of a walnutnut.
They rise above the skin in the form of crimson hemispherical formations. There is the possibility of peripheral growth entities and their merger in the neighboring centers, while there are much larger infiltrates, which can reach the size of the palm of an adult, and sometimes larger.
In addition, in acute leukemia tumors, in contrast to the specific lakemeadow often can disintegrate and transform into a deep and painful ulcer.
Sometimes some patients with a diagnosis of acute leukemia leikemicakie infiltration of the skin can occur the ulcers and necrotic changes, often it is possible to observe As we have said, when skin lesions are foci of tumors can in some cases merge, while they reach quite a large size and occupy large areas of the skin.
In leukemia, the tumor can be located practically anywhere on the skin however this happens most often on the face, thus there is slow ulceration of the affected area. If the tumor is not damaged, it is not accompanied by painful sensations, sometimes a patient may feel not only intense itching.
Nonspecific skin changes
Observed in lymphocytic leukemia most often. While the clinical picture is characterized by:
- urtico-pruriginous elements
- pemphigoides rash.
- trophic changes of the skin.
- eczematous changes. Externally, it can be as antihistamines, antipruritic tools, and also tranquilizers.
Also often used creams with corticosteroids, menthol in alcohol (1-3%), ointments with benzocaine (3-5%).
If skin rashes are too common and cover large areas of skin, they can be accompanied by intolerable itching and even painful sensations, it is recommended to use a corticosteroids prednisone 15-30 mg per day. Here we need to clearly distinguish itching of nerves and itching due to leukemia, with the first to help material on our website dedicated to just mental problems itching.
Patients with specific skin lesions use the appropriate (depending on the form of leukemia) therapies.